/**
 * Copyright (c) 2018-2020 mol* contributors, licensed under MIT, See LICENSE file for more info.
 *
 * @author Alexander Rose <alexander.rose@weirdbyte.de>
 * @author David Sehnal <david.sehnal@gmail.com>
 */

import * as React from 'react';
import { PluginUIComponent } from './base';
import { PluginStateObject as PSO } from '../mol-plugin-state/objects';
import { Sequence } from './sequence/sequence';
import { Structure, StructureElement, StructureProperties as SP, Unit } from '../mol-model/structure';
import { SequenceWrapper } from './sequence/wrapper';
import { PolymerSequenceWrapper } from './sequence/polymer';
import { MarkerAction } from '../mol-util/marker-action';
import { PureSelectControl } from './controls/parameters';
import { ParamDefinition as PD } from '../mol-util/param-definition';
import { HeteroSequenceWrapper } from './sequence/hetero';
import { State, StateSelection } from '../mol-state';
import { ChainSequenceWrapper } from './sequence/chain';
import { ElementSequenceWrapper } from './sequence/element';
import { elementLabel } from '../mol-theme/label';
import { Icon } from './controls/icons';
import { StructureSelectionManager } from '../mol-plugin-state/manager/structure/selection';
import { HelpOutline } from '@material-ui/icons';

const MaxDisplaySequenceLength = 5000;

function opKey(l: StructureElement.Location) {
    const ids = SP.unit.pdbx_struct_oper_list_ids(l);
    const ncs = SP.unit.struct_ncs_oper_id(l);
    const hkl = SP.unit.hkl(l);
    const spgrOp = SP.unit.spgrOp(l);
    return `${ids.sort().join(',')}|${ncs}|${hkl}|${spgrOp}`;
}

function splitModelEntityId(modelEntityId: string) {
    const [ modelIdx, entityId ] = modelEntityId.split('|');
    return [ parseInt(modelIdx), entityId ];
}

function getSequenceWrapper(state: SequenceViewState, structureSelection: StructureSelectionManager): SequenceWrapper.Any | string {
    const { structure, modelEntityId, chainGroupId, operatorKey } = state;
    const l = StructureElement.Location.create(structure);
    const [ modelIdx, entityId ] = splitModelEntityId(modelEntityId);

    const units: Unit[] = [];

    for (const unit of structure.units) {
        StructureElement.Location.set(l, structure, unit, unit.elements[0]);
        if (structure.getModelIndex(unit.model) !== modelIdx) continue;
        if (SP.entity.id(l) !== entityId) continue;
        if (unit.chainGroupId !== chainGroupId) continue;
        if (opKey(l) !== operatorKey) continue;

        units.push(unit);
    }

    if (units.length > 0) {
        const data = { structure, units };
        const unit = units[0];

        let sw: SequenceWrapper<any>;
        if (unit.polymerElements.length) {
            const l = StructureElement.Location.create(structure, unit, unit.elements[0]);
            const entitySeq = unit.model.sequence.byEntityKey[SP.entity.key(l)];
            // check if entity sequence is available
            if (entitySeq && entitySeq.sequence.length <= MaxDisplaySequenceLength) {
                sw = new PolymerSequenceWrapper(data);
            } else {
                const polymerElementCount = units.reduce((a, v) => a + v.polymerElements.length, 0);
                if (Unit.isAtomic(unit) || polymerElementCount > MaxDisplaySequenceLength) {
                    sw = new ChainSequenceWrapper(data);
                } else {
                    sw = new ElementSequenceWrapper(data);
                }
            }
        } else if (Unit.isAtomic(unit)) {
            const residueCount = units.reduce((a, v) => a + (v as Unit.Atomic).residueCount, 0);
            if (residueCount > MaxDisplaySequenceLength) {
                sw = new ChainSequenceWrapper(data);
            } else {
                sw = new HeteroSequenceWrapper(data);
            }
        } else {
            console.warn('should not happen, expecting coarse units to be polymeric');
            sw = new ChainSequenceWrapper(data);
        }

        sw.markResidue(structureSelection.getLoci(structure), MarkerAction.Select);
        return sw;
    } else {
        return 'No sequence available';
    }
}

function getModelEntityOptions(structure: Structure) {
    const options: [string, string][] = [];
    const l = StructureElement.Location.create(structure);
    const seen = new Set<string>();

    for (const unit of structure.units) {
        StructureElement.Location.set(l, structure, unit, unit.elements[0]);
        const id = SP.entity.id(l);
        const modelIdx = structure.getModelIndex(unit.model);
        const key = `${modelIdx}|${id}`;
        if (seen.has(key)) continue;

        let description = SP.entity.pdbx_description(l).join(', ');
        if (structure.models.length) {
            if (structure.representativeModel) { // indicates model trajectory
                description += ` (Model ${structure.models[modelIdx].modelNum})`;
            } else  if (description.startsWith('Polymer ')) { // indicates generic entity name
                description += ` (${structure.models[modelIdx].entry})`;
            }
        }
        const label = `${id}: ${description}`;
        options.push([ key, label ]);
        seen.add(key);
    }

    if (options.length === 0) options.push(['', 'No entities']);
    return options;
}

function getChainOptions(structure: Structure, modelEntityId: string) {
    const options: [number, string][] = [];
    const l = StructureElement.Location.create(structure);
    const seen = new Set<number>();
    const [ modelIdx, entityId ] = splitModelEntityId(modelEntityId);

    for (const unit of structure.units) {
        StructureElement.Location.set(l, structure, unit, unit.elements[0]);
        if (structure.getModelIndex(unit.model) !== modelIdx) continue;
        if (SP.entity.id(l) !== entityId) continue;

        const id = unit.chainGroupId;
        if (seen.has(id)) continue;

        // TODO handle special case
        // - more than one chain in a unit
        let label = elementLabel(l, { granularity: 'chain', hidePrefix: true, htmlStyling: false });

        options.push([ id, label ]);
        seen.add(id);
    }

    if (options.length === 0) options.push([-1, 'No units']);
    return options;
}

function getOperatorOptions(structure: Structure, modelEntityId: string, chainGroupId: number) {
    const options: [string, string][] = [];
    const l = StructureElement.Location.create(structure);
    const seen = new Set<string>();
    const [ modelIdx, entityId ] = splitModelEntityId(modelEntityId);

    for (const unit of structure.units) {
        StructureElement.Location.set(l, structure, unit, unit.elements[0]);
        if (structure.getModelIndex(unit.model) !== modelIdx) continue;
        if (SP.entity.id(l) !== entityId) continue;
        if (unit.chainGroupId !== chainGroupId) continue;

        const id = opKey(l);
        if (seen.has(id)) continue;

        const label = unit.conformation.operator.name;
        options.push([ id, label ]);
        seen.add(id);
    }

    if (options.length === 0) options.push(['', 'No operators']);
    return options;
}

function getStructureOptions(state: State) {
    const options: [string, string][] = [];

    const structures = state.select(StateSelection.Generators.rootsOfType(PSO.Molecule.Structure));
    for (const s of structures) {
        options.push([s.transform.ref, s.obj!.data.label]);
    }

    if (options.length === 0) options.push(['', 'No structure']);
    return options;
}

type SequenceViewState = {
    structure: Structure,
    structureRef: string,
    modelEntityId: string,
    chainGroupId: number,
    operatorKey: string
}

export class SequenceView extends PluginUIComponent<{ }, SequenceViewState> {
    state = { structure: Structure.Empty, structureRef: '', modelEntityId: '', chainGroupId: -1, operatorKey: '' }

    componentDidMount() {
        if (this.plugin.state.data.select(StateSelection.Generators.rootsOfType(PSO.Molecule.Structure)).length > 0) this.setState(this.getInitialState());

        this.subscribe(this.plugin.events.state.object.updated, ({ ref, obj }) => {
            if (ref === this.state.structureRef && obj && obj.type === PSO.Molecule.Structure.type && obj.data !== this.state.structure) {
                this.setState(this.getInitialState());
            }
        });

        this.subscribe(this.plugin.events.state.object.created, ({ obj }) => {
            if (obj && obj.type === PSO.Molecule.Structure.type) {
                this.setState(this.getInitialState());
            }
        });

        this.subscribe(this.plugin.events.state.object.removed, ({ obj }) => {
            if (obj && obj.type === PSO.Molecule.Structure.type && obj.data === this.state.structure) {
                this.setState(this.getInitialState());
            }
        });
    }

    private getStructure(ref: string) {
        const state = this.plugin.state.data;
        const cell = state.select(ref)[0];
        if (!ref || !cell || !cell.obj) return Structure.Empty;
        return (cell.obj as PSO.Molecule.Structure).data;
    }

    private getSequenceWrapper() {
        return getSequenceWrapper(this.state, this.plugin.managers.structure.selection);
    }

    private getInitialState(): SequenceViewState {
        const structureRef = getStructureOptions(this.plugin.state.data)[0][0];
        const structure = this.getStructure(structureRef);
        let modelEntityId = getModelEntityOptions(structure)[0][0];
        let chainGroupId = getChainOptions(structure, modelEntityId)[0][0];
        let operatorKey = getOperatorOptions(structure, modelEntityId, chainGroupId)[0][0];
        if (this.state.structure && this.state.structure === structure) {
            modelEntityId = this.state.modelEntityId;
            chainGroupId = this.state.chainGroupId;
            operatorKey = this.state.operatorKey;
        }
        return { structure, structureRef, modelEntityId, chainGroupId, operatorKey };
    }

    private get params() {
        const { structure, modelEntityId, chainGroupId } = this.state;
        const structureOptions = getStructureOptions(this.plugin.state.data);
        const entityOptions = getModelEntityOptions(structure);
        const chainOptions = getChainOptions(structure, modelEntityId);
        const operatorOptions = getOperatorOptions(structure, modelEntityId, chainGroupId);
        return {
            structure: PD.Select(structureOptions[0][0], structureOptions, { shortLabel: true }),
            entity: PD.Select(entityOptions[0][0], entityOptions, { shortLabel: true }),
            chain: PD.Select(chainOptions[0][0], chainOptions, { shortLabel: true, twoColumns: true, label: 'Chain' }),
            operator: PD.Select(operatorOptions[0][0], operatorOptions, { shortLabel: true, twoColumns: true })
        };
    }

    private get values(): PD.Values<SequenceView['params']> {
        return {
            structure: this.state.structureRef,
            entity: this.state.modelEntityId,
            chain: this.state.chainGroupId,
            operator: this.state.operatorKey
        };
    }

    private setParamProps = (p: { param: PD.Base<any>, name: string, value: any }) => {
        const state = { ...this.state };
        switch (p.name) {
            case 'structure':
                state.structureRef = p.value;
                state.structure = this.getStructure(p.value);
                state.modelEntityId = getModelEntityOptions(state.structure)[0][0];
                state.chainGroupId = getChainOptions(state.structure, state.modelEntityId)[0][0];
                state.operatorKey = getOperatorOptions(state.structure, state.modelEntityId, state.chainGroupId)[0][0];
                break;
            case 'entity':
                state.modelEntityId = p.value;
                state.chainGroupId = getChainOptions(state.structure, state.modelEntityId)[0][0];
                state.operatorKey = getOperatorOptions(state.structure, state.modelEntityId, state.chainGroupId)[0][0];
                break;
            case 'chain':
                state.chainGroupId = p.value;
                state.operatorKey = getOperatorOptions(state.structure, state.modelEntityId, state.chainGroupId)[0][0];
                break;
            case 'operator':
                state.operatorKey = p.value;
                break;
        }
        this.setState(state);
    }

    render() {
        if (this.getStructure(this.state.structureRef) === Structure.Empty) {
            return <div className='msp-sequence'>
                <div className='msp-sequence-select'>
                    <Icon svg={HelpOutline} style={{ cursor: 'help', position: 'absolute', right: 0, top: 0 }}
                        title='This shows a single sequence. Use the controls to show a different sequence.'/>

                    <span>Sequence</span><span style={{ fontWeight: 'normal' }}>No structure available</span>
                </div>
            </div>;
        }

        const sequenceWrapper = this.getSequenceWrapper();

        const params = this.params;
        const values = this.values;

        return <div className='msp-sequence'>
            <div className='msp-sequence-select'>
                <Icon svg={HelpOutline} style={{ cursor: 'help', position: 'absolute', right: 0, top: 0 }}
                    title='This shows a single sequence. Use the controls to show a different sequence.' />

                <span>Sequence of</span>
                <PureSelectControl title={`[Structure] ${PD.optionLabel(params.structure, values.structure)}`} param={params.structure} name='structure' value={values.structure} onChange={this.setParamProps} />
                <PureSelectControl title={`[Entity] ${PD.optionLabel(params.entity, values.entity)}`} param={params.entity} name='entity' value={values.entity} onChange={this.setParamProps} />
                <PureSelectControl title={`[Chain] ${PD.optionLabel(params.chain, values.chain)}`} param={params.chain} name='chain' value={values.chain} onChange={this.setParamProps} />
                {params.operator.options.length > 1 && <>
                    <PureSelectControl title={`[Instance] ${PD.optionLabel(params.operator, values.operator)}`} param={params.operator} name='operator' value={values.operator} onChange={this.setParamProps} />
                </>}
            </div>

            {typeof sequenceWrapper === 'string'
                ? <div className='msp-sequence-wrapper msp-sequence-wrapper-non-empty'>{sequenceWrapper}</div>
                : <Sequence sequenceWrapper={sequenceWrapper} />}
        </div>;
    }
}